This site features developing Web-based software implementing procedures
developed by the Biostatistics and Genetic Epidemiology Team of the National Cancer
Institute's CFRBCCS Informatics Center at the University of California at Irvine.
This is a program developed by Professor Duncan
Thomas of USC as an example of Web-based procedures for sample size calculations
relevant to genetic epidemiology studies using the Family Registries.
Kin-Cohort Power Calculations
This is a program developed by Professors Duncan
Thomas of USC and Alice Whittemore of Stanford to compute expected score, information,
and parameter estimates for a "kin cohort" design resticted to gene carriers.
Design is ascertainment of families through one of three mechanisms, followed by
genotyping of "probands" (again depending on ascertainment mechanism), followed
by testing of all available relatives in "carrier families". All carriers
identified in this fashion (possibly excluding probands) are then treated as a
cohort, analyzed by unconditional logistic regression (i.e., ignoring the family
matching). Optionally, a regressive model for family history can be incorporated.
Dartmouth Biostatistics Homepage
Has other examples of statistical methods implemented in a
Dartmouth's Norris Cotton